We apply synthetic and systems biology approaches to design and build new microbes with novel capabilities, leveraging both engineering and evolutionary principles.

We are interested in developing platform technologies and using them to answer fundamental biological questions. Our research interests are:

  • Genome engineering

  • Human microbiome

  • Synthetic ecosystems

  • Evolution & epistasis

  • New genetic codes

We are based at Columbia University Medical Center in New York City, and are affiliated with the following departments and programs: