High-throughput transcriptomics of 409 bacteria–drug pairs reveals drivers of gut microbiota perturbation
Ricaurte D*, Huang Y*, Sheth RU, Gelsinger DR, Kaufman A, Wang HH
Nature Microbiology doi:10.1038/s41564-023-01581-x (2024) [pdf]
Fast and efficient template-mediated synthesis of genetic variants
Liu L*, Huang Y*, Wang HH
Nature Methods 20:841-848 (2023) [pdf][protocol]
High-throughput microbial culturomics using automation and machine learning
Huang Y*, Sheth RU*, Zhao S, Cohen L, Dabaghi K, Moody T, Sun Y, Ricaurte D, Richardson M, Velez-Cortes F, Blazejewski T, Kaufman A, Ronda C, Wang HH
Nature Biotechnology 41:1424–1433 (2023) [pdf]
Resurrecting essential amino acid biosynthesis in a mammalian cell
Trolle J*, McBee RM*, Kaufman A, Pinglay S, Berger H, German S, Liu L, Shen MJ, Guo X, Martin JA, Pacold M, Jones DR, Boeke JD#, Wang HH#
eLife doi: 10.7554/eLife.72847 (2022) [pdf]
Engineering living and regenerative fungal–bacterial biocomposite structures
McBee RM, Lucht M, Mukhitov N, Richardson M, Srinivasan T, Meng D, Chen H, Kaufman A, Reitman M, Munck C, Schaak D#, Voigt C, Wang HH#
Nature Materials 21:471-478 (2022) [pdf]
Robust direct digital-to-biological data storage in living cells
Yim SS, McBee RM, Song AM, Huang Y, Sheth RU, Wang HH
Nature Chemical Biology 17:246–253 (2021) [pdf]
CRISPR RNA-guided integrases for high-efficiency and multiplexed bacterial genome engineering
Vo PLH, Ronda C, Klompe SE, Chen EE, Acree C, Wang HH, Sternberg SH
Nature Biotechnology 39:480–489 (2020) [pdf]
Synthetic sequence entanglement augments stability and containment of genetic information in cells
Blazejewski T*, Ho HI*, Wang HH.
Science 365:595-598 (2019) [pdf]
Spatial metagenomic characterization of microbial biogeography in the gut
Sheth RU, Li M, Jiang W, Sims PA, Leong KW, Wang HH.
Nature Biotechnology 37:877-883 (2019) [pdf]
Metagenomic engineering of the mammalian gut microbiome in situ
Ronda C*, Chen SP*, Cabral V*, Yaung SJ, Wang HH
Nature Methods 16:167–170 (2019) [pdf]
Metagenomic mining of regulatory elements enables programmable species-selective gene expression
Johns NI*, Gomes ALC*, Yim SS, Yang A, Blazejewski T, Smillie CS, Smith MB, Alm EJ, Kosuri S, Wang HH
Nature Methods 15:323–329 (2018) [pdf]
Multiplex recording of cellular events over time on CRISPR biological tape
Sheth RU, Yim SS, Wu FL, Wang HH
Science 358:1457–1461 (2017) [pdf]